1619

"Hemp cultivation played a crucial role in the early days of settling Jamestown, Virginia. It produced necessary materials used in everyday life (rope, cloth, paper, etc.) Bibles and maps were printed on hemp. Lamp oil was derived from pressed hemp seeds. One single ship in the British naval fleet required 120,000 pounds of hemp fiber, and as a result, the British Crown made farming hemp mandatory for settlers in Jamestown. Each farm cultivated at least one acre of hemp. Farmers who didn’t comply would be fined or jailed."

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"The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa(marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases."

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1966

"Mechoulam joined the faculty of the Hebrew University in Jerusalem. In 1967, he received a research grant from the Institute of Mental Health in the United States to continue his research on hashish. In 1968, he was appointed an associate professor, and in 1972, a full professor, at Hebrew University. In 1975 he was appointed to the Lionel Jacobson chair for medicinal chemistry."

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